What Is NAD+?

NAD+ stands for nicotinamide adenine dinucleotide, a coenzyme found in cells that participates in redox reactions, mitochondrial energy metabolism, DNA repair signaling, and cellular stress responses. NAD+ is not technically a peptide. Injectable or IV NAD+ therapy for general anti-aging or wellness is not FDA-approved.

How It Works

NAD+ participates in cellular energy transfer and serves as a substrate for enzymes such as sirtuins and PARPs. NAD+ levels and related metabolism have become a major research area in aging, metabolism, and mitochondrial function. Increasing NAD+ biomarkers does not automatically prove meaningful clinical anti-aging outcomes.

What It’s Studied For

NAD+ and NAD+ precursors such as NR and NMN have been studied in human trials for effects on NAD+ levels, metabolic markers, physical function, aging-related outcomes, and safety. Reviews generally conclude that biological activity is plausible, but clinical effectiveness for broad anti-aging/wellness outcomes remains uncertain and larger trials are needed.

How It May Be Used in a Clinician-Supervised Program

A licensed clinician may discuss NAD+ support for patients seeking cellular-energy or wellness support after reviewing medical history, medications, pregnancy status, cancer history, liver/kidney issues, and treatment goals. NAD+ does not treat addiction, reverse aging, cure fatigue, or prevent disease.

Preferred Starting Options / Dosing Notes

Many patients begin with a lower starting option so a licensed clinician can evaluate tolerance, medical history, goals, and safety factors before any adjustments are considered. The starting option shown below is informational and reflects available program data, not self-directed dosing instructions. Final medication, dose, frequency, and treatment plan are determined by a licensed clinician.

Safety Considerations

• Limited long-term clinical data for wellness use.
• Possible infusion/injection reactions, nausea, flushing, and chest pressure or discomfort during rapid IV administration.
• Headache, dizziness, and sterility risks for injectables.
• Patients with cancer history, pregnancy, breastfeeding, significant heart disease, or complex medication regimens require clinician review.

Some treatments may involve compounded medications when prescribed by a clinician. Compounded medications are not FDA-approved. The FDA does not evaluate compounded medications for safety, effectiveness, or quality before marketing.

Frequently Asked Questions